10 Medical Studies About Omega 3 Fatty Acids and Bipolar Disorder


Here are ten medical studies about omega-3 fatty acids and bipolar disorder – from the 1990s up to today and all found favorable results. If you have a mood disorder it would be very smart to take a high-quality salmon oil supplement.

10 Medical Studies About Omega 3 Fatty Acids and Bipolar Disorder
Severe Mood States of Bipolar Disorder are Emotionally Painful and Destructive. We All Want to Be Well and Have Some Peace in Our Lives. Yes?

Not for a bipolar cure, but to lessen the severity of episodes and prevent episodes. Omega-3 studies with children show similar positive results.

Related post: Salmon Oil, Fish Oil or Krill Oil – What is Best for Bipolar Disorder?

If you have children help them to take it regularly too. No parent wants their child to develop Manic Depression. Be proactive in preventing onset of the illness.

10 Medical Studies About Omega 3 Fatty Acids and Bipolar Disorder

1. Effects of Omega-3 Supplement in the Treatment of Patients with Bipolar I Disorder. International Journal of Preventative Medicine, May, 2016.

“The results of this study showed that supplements containing omega-3 are useful in the treatment of BID.”

“The use of supplements containing omega-3 along with other treatments is recommended based on the consideration of high prevalence of BID, the impossibility of making this substance in the human body, and the body’s need for external supplements amount of this substance.”

2. Omega-3 for Bipolar Disorder: Meta-analyses of Use in Mania and Bipolar Depression. Journal of Clinical Psychiatry, January, 2012.

“The meta-analytic findings provide strong evidence that bipolar depressive symptoms may be improved by adjunctive use of omega-3.”

“The evidence, however, does not support its adjunctive use in attenuating mania.”

3. Omega 3 Fatty Acids in Bipolar Disorder: A Preliminary Double-blind, Placebo-Controlled Trial. Journal of American Psychiatry, May, 1999.

“Omega-3 fatty acids used as an adjunctive treatment in bipolar disorder resulted in significant symptom reduction and a better outcome when compared with placebo in this pilot study.”

“Improvement was significantly greater in the ω3 fatty acid group than the olive oil control group on almost every assessment measure.”

“The striking difference in relapse rates and response appeared to be highly clinically significant.”

4. Omega-3 Fatty Acid Treatment and T2 Whole Brain Relaxation Times in Bipolar Disorder. The American Journal of Psychiatry, October, 2004.

“Bipolar subjects who received omega-3 fatty acids had significant decreases in T2. There was a dose-dependent effect when the bipolar omega-3 fatty acid group was subdivided into high- and low-dose cohorts.”

“Omega-3 fatty acids lowered T2 values, consistent with the hypothesis that the fluidity of cell membranes was altered.”

“Further studies are needed to clarify the significance of alterations in brain physiology induced by omega-3 fatty acids, as reflected in T2 values.”

5. Efficacy of Ethyl-eicosapentaenoic Acid in Bipolar Depression: Randomised Double-blind Placebo-controlled Study. The British Journal of Psychiatry, January, 2006.

“Significant improvement was noted with ethyl-EPA treatment compared with placebo in the HRSD (P=0.04) and the CGI (P=0.004) scores. Both doses were well tolerated.”

“Adjunctive ethyl-EPA is an effective and well-tolerated intervention in bipolar depression.”

6. A Meta-Analytic Review of Double-Blind, Placebo-Controlled Trials of Antidepressant Efficacy of Omega-3 Fatty Acids. Journal of Clinical Psychiatry, April, 2006.

“In this study, we found omega-3 PUFAs significantly improved depressive symptoms in subjects with mood disorders, with clearly defined depression, or with bipolar disorder.”

“The dosage of EPA did not change the antidepressant efficacy significantly. However, significant heterogeneity among these studies and publication bias were noted.”

7. Omega-3 Fatty Acids Decreased Irritability of Patients with Bipolar Disorder in an Add-on, Open Label Study. Nutrition Journal, February, 2005.

“Omega-3 Fatty Acid intake helped with the irritability component of patients suffering from bipolar disorder with a significant presenting sign of irritability.”

“Low dose (1 to 2 grams per day), add-on O-3FA may also help with the irritability component of different clinical conditions, such as schizophrenia, borderline personality disorder and other psychiatric conditions with a common presenting sign of irritability.”

8. Fats and Factors: Lipid Profiles Associate with Personality Factors and Suicidal History in Bipolar Subjects. PLoS One, January, 2012.

“In previous studies, an effect of n-3 fatty acid supplementation has shown inconsistent association with improvements in bipolar symptomology and we suggest that this may be due to variable concentrations of other lipid species, either n-6 fatty acids that tend to compete with n-3 fatty acids in a variety of signaling, inflammatory and other pathways; or genetically variant enzyme activities that favor pooling one fatty acid over another.”

9. Omega-3 Fatty Acids in Bipolar Disorder: Clinical and Research Considerations. ScienceDirect, 2006.

“The pilot work suggests that it is feasible to conduct an adequately powered trial of the use of o-3 fatty acids in women with BD who choose to discontinue all conventional psychotropic medications while attempting to conceive.”

“Overall, the elucidation of the potential role of o-3 fatty acids as a treatment for BD as well as pregnancy in patients with BD requires further study.”

“The current data are not sufficient to support a recommendation of monotherapy treatment as a substitute for standard pharmacologic treatments.”

“However,judicious monotherapy use in select clinical situations, or adjunctive use, may be warranted pending further data from controlled clinical trials.”

10. Cross-National Comparisons of Seafood Consumption and Rates of Bipolar Disorder. American Journal of Psychiatry, December, 2003.

“These data describe a robust correlational relationship between greater seafood consumption and lower prevalence rates of bipolar disorders.”

“These data provide a cross-national context for understanding ongoing clinical intervention trials of omega-3 fatty acids in bipolar disorders.”

Take a high-quality salmon oil product from wild-caught salmon. And you may help heal your bipolar mood swings and prevent future episodes of severe illness.

Cheers, Molly


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